Each tablet of Glotrim® 480 contains: 

• Sulphamethoxazole         400 mg 
• Trimethoprim             80 mg 

Each 5 ml of Glotrim® Oral Suspension contains:

• Sulfamethoxazole       200 mg 
• Trimethoprim            40 mg 

Glotrim® is used for the treatment of:

• Urogenital infections (caused by Escherichia coli, klebsiella species, Enterobacter species) such as acute and chronic cystitis, urethritis, pyelonephritis and prostatitis. 
• Gastrointestinal infections: including typhoid and paratyphoid fever, bacillary dysentery and cholera. 
• Respiratory tract infections: acute and chronic bronchitis, bronchiectasis pneumonia (including pneumocystis carinii pneumonia), tonsillitis, pharyngitis and acute otitis media in pediatric patients caused by streptococcus pneumonia or haemophilus influenza. 
• Other uses: included the treatment of biliary tract infections, brucellosis, Nocardiosis and skin and soft tissue infections such as acne. 

Glotrim® is contraindicated in: 

• Patients with a known hypersensitivity to the sulphonamides or Trimethoprim. 
• Megaloblastic anemia due to folic acid deficiency.
• During pregnancy and lactation.
• Pediatric patients less than 2 months of age. 
• Severe renal insufficiency or hepatic damage. 
• Patients with serious hematological disorders or with glucose-6-phosphate dehydrogenase deficiency. 

• Glotrim® potentiate the effect of diuretics (thiazide) and oral hypoglycemic agents. 
• Glotrim® may enhance the effect of phenytoin. 
• Glotrim® may prolong the prothrombin time in patients who are receiving the anticoagulant (warfarin).
• Since Glotrim® can reduce the effect of oral contraceptives, female patients should be asked to take additional contraceptives precautions during Glotrim® treatment.

• Glotrim® should not be preferably used during pregnancy, especially in the third trimester, otherwise Glotrim® should be used concomitantly with folic acid.
• The administration of Glotrim® to lactating women represents negligible risk to the sucking infant.

Glotrim® is well tolerated at the recommended doses so any side effects that may occur are mild, these include: 

• Gastrointestinal disturbances such as: nausea, vomiting, anorexia. 
• Allergic skin reactions. 
• Hematological changes may be observed in some patients, particularly in elderly patients.
• Chronic dosage can cause bone marrow depression. 

Over dosage:

• Nausea, vomiting, headache, dizziness.

Adults and children over 12 years old : 

• Usual dose: two tablet of Glotrim® twice daily for five days . 
• High dosage for severe infections: three tablets of Glotrim® twice daily.
• Minimum dosage and dosage for long term treatment: One tablet of Glotrim® twice daily.

Children:

• 6- 12 years of age: one tablet of Glotrim® 480  twice daily or 2 teaspoonfuls (10ml) of Glotrim® oral suspension twice daily  
• 1- 6 years: 1 teaspoonfuls (5 ml) of Glotrim® oral suspension twice daily.
• Infants 2- 12 months:  1/ 2 teaspoonfuls (2.5 ml) of Glotrim® oral suspension twice daily.

In the treatment of Pneumocystis carinii pneumonia:

• 120 mg /kg dailyin 2 to 4 divided doses for 14 to 21 days in adults 
• children over 4  weeks of age.    

Norcardiosis:

• doses 2.88g to 3.84g daily in  divided doses for up to 3 months have been used .        

*Glotrim® is ideally taken after meals with plenty of water or fluid.

Glotrim® should be given with caution to: 

• Elderly patients. 
• Patients with impaired renal or hepatic function. 
• Patients with severe allergic or bronchial asthma. 

* Glotrim® should be discontinued if skin rash appears. 

* Urine analysis and renal function tests should be performed during long term therapy. 

• Glotrim® 480 mg tablet: Blisters of 10 Tablets, Packs of  2 blisters.
• Glotrim® oral suspension: Bottles of 100 ml&Bottles of 60 ml.

* Hospital packs with different sizes.

• Store in a dry place at a temperature not exceeding 25oC.