Vezol® suspension
Vezol® suspension
treatment of helminth infestations
Indication
Vezol ® suspension is indicated for the treatment of single and mixed helminth infestations caused by:
- Trichuris trichiura (whipworm)
- Ancylostoma duodenale (hookworm)
- Necator americanus (hookworm)
- Ascaris lumbricoides (large roundworm)
- Enterobius vermicularis (pinworm)
- Strongyloides stercoralis (threadworm)
- Taenia spp. (tapeworm)
Composition
Each 5ml of Vezol® suspension contains:
- Mebendazole 100 mg
Dosage
Whipworm ,Hookworm ,Ascaris, Pinworm:
- Adults and Children: 5 mL twice daily (morning and evening) for three consecutive days.
Tapeworm (Taenia spp):
- Adults and Children: 5 mL twice daily (morning and evening) for six consecutive days.
Threadworm (Strongyloides stercoralis):
- Adults: 10 mL twice daily (morning and evening) for three consecutive days.
- Children: 5 mL twice daily (morning and evening) for three consecutive days.
- The active component of Vezol® suspensions is Mebendazole which is a broad-spectrum anthelmintic.
- It appears to affect the cytoplasmic microtubules of the tegumental or intestinal cells of parasitic worms resulting in a transport blocking of secretory vesicles. This may lead to impaired coating of the membranes followed by a decreased digestion and absorption of nutrients, e.g.glucose, thereby depleting the energy level until it is inadequate for survival.
Each 5ml of Vezol® suspension contains:
- Mebendazole 100 mg
Vezol ® suspension is indicated for the treatment of single and mixed helminth infestations caused by:
- Trichuris trichiura (whipworm)
- Ancylostoma duodenale (hookworm)
- Necator americanus (hookworm)
- Ascaris lumbricoides (large roundworm)
- Enterobius vermicularis (pinworm)
- Strongyloides stercoralis (threadworm)
- Taenia spp. (tapeworm)
- Hypersensitivity to mebendazole.
- Metabolism of mebendazole may possibly be inhibited by cimetidine Therefore, upon concurrent of administration, plasma concentration of mebendazole may be increased.
- Vezol ® suspension should not be used during pregnancy and lactation.
- Vezol® is usually very well tolerated.Rarely, gastrointestinal disturbances including abdominal pain and diarrhea have been experienced, particularly in patients with heavy intestinal infection.
- Hypersensitivity reactions including exanthema, rash, urticaria, and angioedema have rarely been reported with use of mebendazole.
Over dosage:
- In the event of accidental over dosage,abdominal cramps, nausea,vomiting and diarrhea may occur.
- There is no specific antidote. Within the first hour after ingestion, gastric lavage may be performed.
Whipworm ,Hookworm ,Ascaris, Pinworm:
- Adults and Children: 5 mL twice daily (morning and evening) for three consecutive days.
Tapeworm (Taenia spp):
- Adults and Children: 5 mL twice daily (morning and evening) for six consecutive days.
Threadworm (Strongyloides stercoralis):
- Adults: 10 mL twice daily (morning and evening) for three consecutive days.
- Children: 5 mL twice daily (morning and evening) for three consecutive days.
- Usage in children below 2 years is not well documented and as there have been very rare reports of convulsions in this age group.
- Vezol® suspension: Bottle of 30 ml oral suspension.
- Store at temperature below 30°C and protected from light.