Each film-coated tablet of Moxival® contains:

• Moxifloxacin      400 mg 

¤ Moxifloxacin should only be used to treat these infections when usual antibiotics cannot be used or have not worked

¤ Moxival®  is used in patients of 18 years of age and older for treating the following bacterial infections when caused by bacteria against which Moxifloxacin is active:

• Community Acquired Pneumonia
• Uncomplicated Skin And Skin Structure Infections.
• Complicated Skin And Skin Structure Infections. 
• Complicated Intra-Abdominal Infections.
• Acute Bacterial Sinusitis.
• Acute Bacterial Exacerbation of Chronic Bronchitis

Moxival® is contra-indicated in

• patients with a history of hypersensitivity to Moxifloxacin or other quinolone derivatives.
• If you are younger than 18 years of age. 
• If you are pregnant or breast-feeding.
• If you have a severe liver disease or increased liver enzymes (transaminases) higher than 5 times the upper normal limit.
• If you have a salt imbalance in the blood (especially low levels of potassium or magnesium in the blood).
• If you have a weak heart (heart failure),bradycardia,abnormal heart 
   rhythms.
• If you are taking other medicines that result in abnormal ECG changes  
  This is because Moxifloxacin can cause changes on the ECG, that is a   
  prolongation of the QT-interval, i.e., delayed conduction of electrical  
  signals 

¤ If you are taking Moxival® and other medicines that affect your heart there is an increased risk for altering your heart beats. Therefore, do not take Moxival® together with the following medicines:

• Medicines that belong to the group of anti-arrhythmics (e.g.quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide)
• neuroleptics (e.g.phenothiazines, pimozide, sertindole , haloperidol , sultopride).
• tricyclic antidepressants
• some antimicrobials (e.g. sparfloxacin, intravenous erythromycin, pentamidine )
• antimalarials particularly halofantrine,
• some antihistamines (e.g. terfenadine,astemizole, mizolastine)
• and other medicines (e.g. cisapride, intravenous vincamine,  and diphemanil).

¤ On the other hand, reduce the absorption of Moxival® and related drugs when given concomitantly with :

• Cations like aluminum, magnesium
• iron 

( should be after or before 2 hours of Moxival® adminstration ).  

As with other quinolones, side effects are usually: 

• Gastro-intestinal disturbances include: nausea, vomiting, diarrhoea, abdominal pain and dyspepsia.
• Headache, dizziness, Hypokalemia 
• Infections caused by resistant bacteria or fungi e.g.oral and vaginal infections caused by Candida.
• change of the heart rhythm (ECG) in patients with low blood potassium level.
• Hypersensitivity type reactions affecting the skin, in addition  to rash and pruritis.

¤ The recommended dose is one 400 mg film-coated tablet once daily.

¤ The film-coated tablet should be swallowed whole with sufficient liquid and may be taken with or without the meals.

Duration of administration:

¤ Moxifloxacin 400 mg film-coated tablets should be used for the following Treatment durations:

• Community Acquired Pneumonia                             5 - 14 days
• Uncomplicated Skin And Skin Structure Infections.        7 days
• Complicated Skin And Skin Structure Infections      5 - 21 days
• Complicated Intra-Abdominal Infections.                 5 - 14 days 
• Acute Bacterial Sinusitis                                                    7 days
• Acute Bacterial Exacerbation Of Chronic Bronchitis        5 days

Moxival® should be used with caution in patients with:

• epilepsy ,myasthenia gravisor ,complicated infection of the female upper genital tract , glucose-6-phosphate dehydrogenase deficiency.
• During treatment, patients should not expose themselves to sunlight, UV rays (due to photosensitivity reactions.) 
• Avoid driving or other activities requiring alertness. 

• Moxival® Film coated tablet 400 mg (Blister of 5Tablets, Box of one blister).

• Store in a dry place at a temperature not exceeding 30° C.