Dentacin® forte
Dentacin® forte
anti-parasitic and anti-anaerobic bacterial
Indication
Dentacin® is highly effective in the treatment of acute, chronic and relapsing stomatologic infections such as:
- Buccodental infections due to aerobic and anaerobic germs sensitive to Spiramycin and Metronidazole.
- Dental infections as in dental abscesses, stomatitis, aphthous ulcer, perimaxillar cellulites, pericoronitis, periodonitis and eriodontal infection.
- Parotiditis and submaxillaritis.
- Pre and post-operative prophylaxis in odontostomatologic surgery.
- Tonsilitis and gingivitis .
- Dentacin® can be efficacious in the treatment of those patients with AIDS and diarrhea in which cryptospordium is identified.
Composition
Each film coated tablet of Dentacin® forte contains:
- Spiramycin 150000 IU
- Metronidazole 250 mg
Each film coated tablet of Dentacin® contains:
- Spiramycin 750000 IU
- Metronidazole 125 mg
Dosage
Dentacin® is recommended to be used during meals.
Children:
- 6-10 years : 1 tablet of Dentacin® 2 times daily.
- 10-15 years : 1 tablet of of Dentacin® 3 times daily.
Adults:
- 2 tablets of Dentacin® 2-3 times daily.
- Or one tablet of Dentacin® forte 2-3 times daily.
- Spiramycin is a macrolide bacteriostatic antibiotic with an antimicorbial spectrum similar to that of erythromycin and clindamycin.
- Metronidazole a 5-nitroimidazle derivative is active against various anaerobic bacteria and protozoa .
- The complementary combination of Spiramycin and Metronidazole shows synergism in inhibiting certain sensitive bacteria involved in buccodental infections.
- Spiramycin is incompletely absorbed from gastro-intestinal tract and is widely distributed in the tissues. It has a half- life of about 8 hours.
- Spiramycin is metabolised in the liver to active metabolites; substantial amount are excreted in the bile and about 10% in the urine. It is distributed in to breast milk.
- Metronidazole is readily absorbed after oral administration and bioavailability approaches 100%.
- Metronidazole has a large volume of distribution in the body. It crosses the placenta.
- Metronidazole is metabolized in the liver and It’s elimination half life is about 8 hours.
- The majority of dose of Metronidazole is excreted in the urine mainly as metabolites; a small amount appears in the faeces.
Each film coated tablet of Dentacin® forte contains:
- Spiramycin 150000 IU
- Metronidazole 250 mg
Each film coated tablet of Dentacin® contains:
- Spiramycin 750000 IU
- Metronidazole 125 mg
Dentacin® is highly effective in the treatment of acute, chronic and relapsing stomatologic infections such as:
- Buccodental infections due to aerobic and anaerobic germs sensitive to Spiramycin and Metronidazole.
- Dental infections as in dental abscesses, stomatitis, aphthous ulcer, perimaxillar cellulites, pericoronitis, periodonitis and eriodontal infection.
- Parotiditis and submaxillaritis.
- Pre and post-operative prophylaxis in odontostomatologic surgery.
- Tonsilitis and gingivitis .
- Dentacin® can be efficacious in the treatment of those patients with AIDS and diarrhea in which cryptospordium is identified.
- Hypersensitivity to Spiramycin and/or Metronidazole.
- Concomitant use of Ergotamine or other vasoconstrictor derivatives of ergot.
- Concomitant use of Disulfiram.
- Spiramycin Inhibit the absorption of Carbidopa accompanied by decrease in plasma levels of levodopa, hence, the dose adaptation and clinical monitoring of levodopa is recommended.
- Drugs that may affect Metronidazole include Barbiturates and Cimetidine.
- Drugs that may affected by Metronidazole include Anticoagulants, Disulfiram, Hydantoins and Lithium.
- Spiramycin may increase serum Theophylline concentration.
- Spiramycin can increase the effects of oral Anticoagulants and Digoxin.
- Dentacin® should not be used in the first trimester of pregnancy and lactation.
- Lactating women those must use Dentacin® should stop lactation during treatment period.
Dentacin® forte tablets are well tolerated.
The most common side effects are:
- Mild gastrointestinal disturbances as nausea, vomiting, diarrhea, unpleasant taste and darkening of urine may occur.
- Rare case of rash, vertigo, ataxia and leukopoenia.
Dentacin® is recommended to be used during meals.
Children:
- 6-10 years : 1 tablet of Dentacin® 2 times daily.
- 10-15 years : 1 tablet of of Dentacin® 3 times daily.
Adults:
- 2 tablets of Dentacin® 2-3 times daily.
- Or one tablet of Dentacin® forte 2-3 times daily.
- The treatment should be discontinued in case of ataxia and vertigo.
- Alcoholic drinks should be avoided during treatment.
- Dentacin® should be used with great care in patients with blood dyscrasias or with active diseases of the central nervous system.
- Dentacin® should be used cautiously in patients with hepatic dysfunction.
- The dosage of oral–anticoagulants( e.g. warfarin) should be adapted when associated with Dentacin®.
Dentacin® forte:
- Blister of 10 tablets, Pack of one blister.
Dentacin®:
- Blister of 10 tablets, Pack of two blister.
¤ Hospital packs of different sizes.
- Store in a dry place at a temperature below 30ºC.