Indication
- BUSCONIL® is mainly indicated in the treatment of visceral spasm and Hypermotility in cases of: Infant colics, spastic colitis, spastic bladder, cystitis, pylorospasm and associated abdominal cramps.
- It can also be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries and diverticulitis or as adjunctive to control the gastric hypersecretion .
- It can also be used in the therapy of poisoning with
anticholinesterase agents .
Composition
Each 1 ml syrup contains:
- Hyoscyamine sulfate 0.125 mg
Dosage
- Infants (2.5 - 3.5kg): 3- 4 Drops.
- Infants (5 - 7kg): 6- 7 Drops.
- Infants (8 - 10kg): 8- 10 Drops.
- Children (1 -10 years): 0.5 – 1 ml.
- Adults: 1 – 2 ml .
¤ The above doses can be repeated every four hours as needed.Dosage adjustment may be necessary according to conditions and severity of symptoms.
- Hyoscyamine sulfate is a tertiary amine antimuscarinic alkaloid with both central and peripheral actions .It has antispasmodic actions on smooth muscle and reduces secretions, especially salivary and bronchial secretions. When given orally it specifically inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervations, therefore it inhibits the gastrointestinal propulsive motility and controls the excessive pharyngeal, tracheal and bronchial secretions, but it has little effect on gastric secretion in usual therapeutic doses.
Each 1 ml syrup contains:
- Hyoscyamine sulfate 0.125 mg
- BUSCONIL® is mainly indicated in the treatment of visceral spasm and Hypermotility in cases of: Infant colics, spastic colitis, spastic bladder, cystitis, pylorospasm and associated abdominal cramps.
- It can also be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries and diverticulitis or as adjunctive to control the gastric hypersecretion .
- It can also be used in the therapy of poisoning with
anticholinesterase agents .
BUSCONIL® is contraindicated in the following cases:
- Hypersensitivity to Hyoscyamine sulfate or any anticholiner gicdrugs.
- Glaucoma.
- Myasthenia gravis and toxic megacolon.
- Cardiovascular diseases : tachycardia and myocardial ischemia.
- Gastro-intestinal obstructive disease, paralytic ileus , intestinal atony, ulcerativecolitis and hepatic diseases.
- Genito-urinary system : obstructive uropathy and renal
diseases .
¤ The effect of Hyoscyamine sulfate may be enhanced by concomitant administration of other drugs with antimuscarinic properties such as :
- Amantadine, Tricyclic antidepressants, Quinidine, some Antihistamines, Phenothiazine & Antipsychotics.
¤ The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs.
¤ Antimuscarinics and parasympathomimetics may counteract each other’s effects.
- Caution is recommended in pregnancy and lactation.
-Hyoscyamine sulfate may produce some undesirable side effects such as:
- Dryness of the mouth, urinary hesitancy and retention, blurred vision, mydriasis with cycloplegia, transient bradycardia followed by tachycardia with palpitations, increased ocular tension, constipation, headache, drowsiness, nervousness, decrease sweating, allergic reactions, urticaria and other dermal manifestations.
-In case of overdosage:
- anticholinergic symptoms as urinary retention, dry mouth, reddening of the skin, tachycardia and
- Infants (2.5 - 3.5kg): 3- 4 Drops.
- Infants (5 - 7kg): 6- 7 Drops.
- Infants (8 - 10kg): 8- 10 Drops.
- Children (1 -10 years): 0.5 – 1 ml.
- Adults: 1 – 2 ml .
¤ The above doses can be repeated every four hours as needed.Dosage adjustment may be necessary according to conditions and severity of symptoms.
¤ BUSCONIL® needs to be used with caution in :
- Heart diseases, hypertension, hyperthyroidism, and hiatal hernia associated with reflux esophagitis .
¤ In the presence of high environmental temperature heat prostration can occur with the drug use due to decreased sweating.
¤ Hyoscyamine sulfate may also produce drowsiness or blurred vision, therefore, the patient should be warned not to be engaged in activities requiring alertness.
- Bottle of 15 ml solution with dropper.
- Store at temperature not exceeding 25°C protect from direct sunlight.