Zyracin® syrup
Long acting anti-histamine syrup
  • Zyracin® contains Cetirizine hydrochloride which is described as a long-acting antihistamine with antiallergic effects.
  • Cetirizine inhibits the histamine – mediated early phase of the allergic reaction and also reduces the migration of certain inflammatory cells such as eosinophils and the release of certain mediators associated with the late allergic response. 
  • It markedly reduces bronchial hyperreactivity to histamine in the asthmatic patients and also reduces the allergic reaction induced by specific allergens. 
  • It induces neither sedation nor behavioral changes; this maybe explained by the fact that cetirizine does not cross the blood brain barrier.
  • Cetirizine is rapidly absorbed from the GIT after oral doses; peak plasma concentrations being attained  within about an hour. 
  • Cetirizine is excreted primarily in urine mainly as unchanged drug.  

Each film coated tablet of Zyracin® contains: 

  • Cetirizine Hydrochloride     10 mg.

Each 5 ml of Zyracin® syrup contains:

  • Cetirizine Hydrochloride     5 mg.

Zyracin® is used for the symptomatic relief of allergic conditions including:

  • perennial and seasonal allergic rhinitis.
  • pruritus.
  • chronic urticaria .
  • allergic conjunctivitis.

Zyracin® is contraindicated in

  • the hypersensitivity to cetirizine or any of the formulation.
  • Patients with severe renal impairment.
  • Patients with rare hereditary problems of fructose intolerance should not take cetirizine 1 mg/ml oral solution.
  • There was a small decrease in the clearance of Cetirizine Hydrochloride when taken with CNS depressants or anticholenergics. 
  • Zyracin® should not be given to pregnant women during
    the first three months of pregnancy nor should women who are breast-feeding take the drug.
  • Mild and transient side effects such as headache, sedation, dizziness, drowsiness, agitation, dry mouth and GITdiscomfort.
  • Hypersensitivity reaction including skin reaction and angio-edema may occur
  • If you notice any undesirable effects that are not mentioned in this leaflet, please inform your doctor or the pharmacist.


  • In adult drowsiness may be a symptom of over dosage, occuring from administration of 50 mg as a single dose, In children agitation may occur.
  • Treatment should be symptomatic and supportive with gastric lavage.

Adults and children over 6 years:

  • Tablets: one tablet (10 mg) once daily or half tablet (5 mg) twice daily.
  • Syrup: 10 ml once daily or 5 ml twice daily.

Children 2–6 years:

  • 5 ml once daily or 2.5 ml twice daily.

Children between 1–2 years:

  • 2.5 mg twice daily (5 drops twice daily).

Infant less than 1 year:

  • not recomended.
  • Zyracin® should be used with caution in patients with hepatic or renal impairment, elderly patients, prostatic hypertrophy and epilepsy as the dose should be adjusted.
  • Zyracin® may reduce alertness and additional impairment of CNS performance. Hence, patients are advised to avoid driving a car, operating potentially dangerous machinery, drinking alcohol or concomitant administration of CNS depressants with cetirizine.  
  • Zyracin® Tablet : Blister of 10 tablets, pack of 2 blisters.
  • Zyracin® Syrup : Bottle of 60 ml syrup.
  • Store at temperature not exceeding 25 °C, protect from light.