Profast 100
Analgesic , Antirheumatin, Anti-Inflammatory

¤ Ketoprofen, a propionic acid derivative as NSAIDs.

  • Ketoprofen as other NSAIDs, that main use as analgesic, anti-inflammatory and antipyretic. It acts by its inhibitory action on cyclo-oxygenase, which are involved in the biosynthesis of prostaglandin and thromboxane from arachidonic acid.
  • Ketoprofen is readily absorbed from the GIT, peak plasma concentrations occur about 0.5 to 2 hours after dose.
  • Ketoprofen is 99%  bound to plasma proteins, and the elimination half life in plasma is about 1.5 to 4 hours.
  • Ketoprofen is secreted into breast milk.
  • Ketoprofen is metabolised mainly by conjugation with glucuronic acid, and is excreted mainly in the urine.

Each film coated tablet of Profast® contains: 

  • Ketoprofen           100 mg

Profast® is indicated for adults and children over 15 years for the following cases:

  • Long-term treatment of certain chronic inflammatory rheumatism and certain  painful and disabling osteo-arthritis.
  • Short-term treatment during acute exacerbation of joint inflammation such as tendinitis, bursitis, acute shoulder pain, microcrystalline arthritis such as gout, osteo-arthritis, lumbago, radiculalgia such as sciatica, pains and odemas of the locomotor system due to trauma.
  • Post-opertive pain, dysmenorrhoea and to reduce fever. 
  • Hypersensitivity for ketoprofen.
  • Gastrointestinal hemorrhage, cerebrovascular hemorrhage or other hemorrhage in progress.
  • Serious liver, kidney or heart diseases.

Profast® must not be used with:

  • other NSAIDs including aspirin at high doses, oral anticoagulants, heparin at curative or at prophylactic doses or in the elderly , lithium , methotrexate, platelet aggregation inhibiting drugs , potassium salts, diuretics, inhibitors of angiotensin converting enzyme, cyclosporin and tacrolimus trimethoprim, beta-blockers, intrauterine, and pentoxifylline.
  • During the first five months of pregnancy Profast® prescribed only by physician if necessary.
  • As of the 6th month of pregnancy, Profast® must not be taken in any case since its serious effect on the child, and if Profast® have taken, physician should be informed.
  • Profast® is not recommended to be used during lactation. 
  • Gastrointestinal disorders: Nausea, vomiting, diarrhea, constipation, stomach pain, gastrointestinal discomfort, gastritis, stomatitis and more rarely colitis.
  • skin allergies: Eruption, rash, pruritus, urticaria or skin photosensitivity.
  • Headache, dizziness, drowsiness, allopecia, tinnitus, blurred vision, thrombocytopenia, rare cases of leucopenia, possibility of agranulocytosis, hypertension and odema.

¤ Profast® should be taken with a large glass of water, during meals.  

  • In long-term symptomatic treatment: 100- 200 mg / day, to be divided 1 to 3 intakes per day.
  • In short-term symptomatic treatment of acute exacerbation: 300 mg / day, to be divided 1 to 3 intakes per day.
  • In painful conditions including dysmenorrhoea: 25 to 50 mg  every 6 to 8 hours.

¤ Caution is necessary when Profast® is prescribed with the following cases:

  • History of asthma associated with a chronic rhinitis, chronic sinusitis, polyps in the nose or that resulted from other NSAIDs.
  • Coagulation disorders, during concomitant anticoagulant treatment or platelet aggregation inhibiting drugs treatment specially in the elderly, or in weakness or low body weight patients.
  • History of GIT disorders (e.g.  previous gastric or duodenal ulcer, ulcerative colitis, crohn’s disease).
  • Heart, liver or kidney disease, treatment with diuretics or recent surgery.
  • History of skin reaction during exposure to sun or UV rays.
  • Congenital galactosemia, glucose or galactose malabsorption or lactose deficiency.
  • During long-term treatment : monitoring of blood cell count, hepatic (Transaminase serum level) and renal function is recommended.

Note :

  • Driving or using machines should be avoided as dizziness, drowsiness, convulsions or visual disorders may be produced.
  • Profast® film coated tablet (Blisters of 15 tablets, pack of two blisters).
  • Hospital packs of different sizes.
  • Store in a temperature not exceeding 25ºC.