Goxime global ® 400
Broad-spectrum antibiotic

Cefixime is a broad spectrum semi-synthetic third generation cephalosporin antibiotic for oral administration.

  • The bactericidal action of Cefixime results from inhibition of cell wall synthesis. Cefixime is highly beta- lactamase stable, so many bacteria that resist penicillins and other cephalosporins are susceptible to Cefixime.
  • About 40 -50 % of Cefixime is absorbed, peak serum concentrations occur between 2- 6 hours after oral administration, approximately 50% of absorbed dose is excreted unchanged in urine within 24 hours.Food delay the rate of absorption of Cefixime .
  • Cefixime has been shown to be active against most strains of the following Gram-positive and Gram-negative organisms: Streptococcus pneumonia, Streptococcus pyogenes, Streptococcus agalctiae, Haemophilus influenzae, Haemophilus parainfluenae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia species, Salmonella species, Shigella species, Citrobacter diversus, Serratia marcescens.

Each capsule of Goxime ® 400 contains:-

  • Cefixime 400 mg (as Cefixime Trihydrate ).

Each capsule of Goxime ® 200 contains:-

  • Cefixime 200 mg (as Cefixime Trihydrate ).

 

Goxime® is indicated for the treatment of :

  • Pharyngitis, tonsillitis and sinusitis.
  • Acute bronchitis. 
  • Acute exacerbation of chronic bronchitis. 
  • Otitis media. 
  • Uncomplicated urinary tract infections.
  • Uncomplicated urethral or cervical gonorrhea. 
  • GOXIME® is contraindicated in patient with known allergy to the Cefixime or other cephalosporins. Careful inquiry should be made to determine whether the patient has previous hypersensitivity to Cefixime or not.
  • GOXIME® may increase prothrombin time, when used for patients receiving anti-coagulants.
  • Carbamazepine levels elevated when administered concomitantly with GOXIME®.
  • Propencid increase plasma concentration of GOXIME® when administrated concomitantly with GOXIME®.
  • With food: food delay the rate of absorption of GOXIME®.
  • There is no adequate studies in pregnant women, so GOXIME® should be used during pregnancy only if necessary.
  • It is not known whether GOXIME® is excreted in human milk or not.

Side effects are mild and transient in nature.

- The most frequently adverse effects are:

  • gastrointestinal disturbances as (diarrhea, abdominal pain, nausea &vomiting). (GOXIME® should be stopped if diarrhea is severe).

- Other side effects are:

  • skin rashes.
  •  urticaria.
  •  transient elevation in liver enzymes.

Over dosage:-

  • Gastric lavage may be indicated, otherwise no specific antidote exists.

*Adults, children (over 12 years and children over 50kg weight):

  • 400 mg daily, given as a 400mg capsule once daily or as 200mg every 12 hours. 
  • For the treatment of uncomplicated urethral or cervical gonococcal infections, a single oral dose of 400mg is recommended.

 *Children: 
The recommended dose is 8mg/kg/day of suspension. This may be administered as a single daily dose or may be given in two divided doses, as 4mg/kg every 12 hours. 

  • Prolonged use of antibiotic may results in over growth of non-susceptible organisms, so careful observation of patient is essential.

GOXIME® 400 ( Blister of 6 capsules, pack of one Blister).

  • Store in a dry place at a temperature below 25 °C.