Glotrim® 480
broad spectrum anti bacterial
  • Glotrim® is a synthetic antibacterial combination product, it exerts its action by sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid (Tetra hydro folic acid) which is necessary for DNA synthesis in the micro-organisms. 
  • Glotrim® is rapidly absorbed from the gastrointestinal tract following administration. Peak blood levels for the individual components occur 1 to 4 hours after oral administration.
  • Glotrim® diffuses freely throughout the body tissues and fluids including: kidneys, liver, lung, saliva, bile, prostatic tissue and fluid, and vaginal secretions. It can crosses the placenta and detected in the breast milk.
  • Glotrim® is metabolized in the liver and eliminated primarily by the kidneys. 

Each tablet of Glotrim® 480 contains: 

  • Sulphamethoxazole         400 mg 
  • Trimethoprim             80 mg 

Each 5 ml of Glotrim® Oral Suspension contains:

  • Sulfamethoxazole       200 mg 
  • Trimethoprim            40 mg 

Glotrim® is used for the treatment of:

  • Urogenital infections (caused by Escherichia coli, klebsiella species, Enterobacter species) such as acute and chronic cystitis, urethritis, pyelonephritis and prostatitis. 
  • Gastrointestinal infections: including typhoid and paratyphoid fever, bacillary dysentery and cholera. 
  • Respiratory tract infections: acute and chronic bronchitis, bronchiectasis pneumonia (including pneumocystis carinii pneumonia), tonsillitis, pharyngitis and acute otitis media in pediatric patients caused by streptococcus pneumonia or haemophilus influenza. 
  • Other uses: included the treatment of biliary tract infections, brucellosis, Nocardiosis and skin and soft tissue infections such as acne. 

Glotrim® is contraindicated in

  • Patients with a known hypersensitivity to the sulphonamides or Trimethoprim. 
  • Megaloblastic anemia due to folic acid deficiency.
  • During pregnancy and lactation.
  • Pediatric patients less than 2 months of age. 
  • Severe renal insufficiency or hepatic damage. 
  • Patients with serious hematological disorders or with glucose-6-phosphate dehydrogenase deficiency. 
  • Glotrim® potentiate the effect of diuretics (thiazide) and oral hypoglycemic agents. 
  • Glotrim® may enhance the effect of phenytoin. 
  • Glotrim® may prolong the prothrombin time in patients who are receiving the anticoagulant (warfarin).
  • Since Glotrim® can reduce the effect of oral contraceptives, female patients should be asked to take additional contraceptives precautions during Glotrim® treatment.
  • Glotrim® should not be preferably used during pregnancy, especially in the third trimester, otherwise Glotrim® should be used concomitantly with folic acid.
  • The administration of Glotrim® to lactating women represents negligible risk to the sucking infant.

Glotrim® is well tolerated at the recommended doses so any side effects that may occur are mild, these include: 

  • Gastrointestinal disturbances such as: nausea, vomiting, anorexia. 
  • Allergic skin reactions. 
  • Hematological changes may be observed in some patients, particularly in elderly patients.
  • Chronic dosage can cause bone marrow depression. 

Over dosage:

  • Nausea, vomiting, headache, dizziness.

Adults and children over 12 years old : 

  • Usual dose: two tablet of Glotrim® twice daily for five days. 
  • High dosage for severe infections: three tablets of Glotrim® twice daily.
  • Minimum dosage and dosage for long term treatment: One tablet of Glotrim® twice daily.


  • 6- 12 years of age: one tablet of Glotrim® 480  twice daily or 2 teaspoonfuls (10ml) of Glotrim® oral suspension twice daily  
  • 1- 6 years: 1 teaspoonfuls (5 ml) of Glotrim® oral suspension twice daily.
  • Infants 2- 12 months:  1/ 2 teaspoonfuls (2.5 ml) of Glotrim® oral suspension twice daily.

In the treatment of Pneumocystis carinii pneumonia:

  • 120 mg /kg dailyin 2 to 4 divided doses for 14 to 21 days in adults 
  • children over 4  weeks of age.    


  • doses 2.88g to 3.84g daily in  divided doses for up to 3 months have been used .        

*Glotrim® is ideally taken after meals with plenty of water or fluid.

Glotrim® should be given with caution to

  • Elderly patients. 
  • Patients with impaired renal or hepatic function. 
  • Patients with severe allergic or bronchial asthma. 

* Glotrim® should be discontinued if skin rash appears. 

* Urine analysis and renal function tests should be performed during long term therapy. 

  • Glotrim® 480 mg tablet: Blisters of 10 Tablets, Packs of  2 blisters.
  • Glotrim® oral suspension: Bottles of 100 ml&Bottles of 60 ml.

* Hospital packs with different sizes.

  • Store in a dry place at a temperature not exceeding 25oC.