• Drotaverine HCL is an isoquinoline derivative,which has spasmolytic action on smooth muscle of the coronary and peripheral arteries, and uro- 
    genital tract.
  • Its action is due to surface activity by binding to the surface of smooth muscle. It acts by elevation of cAMP level, through phosphodiesterase 
    inhibition, it normalizes the smooth muscle tone bringing the hypertonic state to a normatonic state.
  • Drotaverine HCL is well tolerated by humans, it has spasmolytic action stronger than papaverine.
  • Its protein binding is lower, its effect develops more rapidly, slowly released and last longer than that at papaverine and perparine.
  • The absorption of drotaverine HCL is extremely rapid, within 12 minutes. The peak plasma levels reach between 45 and 60 minutes indicating rapid absorption.
  • The half life of drotaverine HCL is 6 hours, regardless the route of administration.
  • Drotaverine HCL is metabolized by the liver and excreted in the bile (50%) & urine (30%). The elimination of drotaverine is practically completed within 72 hours.

Each tablet of GLO SPA® contains: 

  • Drotaverine HCL 60 mg

GLO SPA® is used as antispasmodic in the management of:

  • Gastrointestinal tract, genito-urinary tract, and billiary tract. 
  • Gynaecology and obstetrics: specially in spasmodic dysmenorrhoea, threatening abortion and to regulate the uterine contractions during
  • Cardiovascular system: as an adjuvant in angina pectoris, coronary insufficiency and in hypertensive patients.
  • Otorhinolaryngology: spastic disorders in meniere's disease, and tinnitus of vascular origin caused by spasm of tensor tympani muscle.

GLO SPA® is contraindicated in the following cases:

  • Hepatic, renal-cardic disease.
  • Known hypersensitivity to the drotaverine HCL.
  • GLO SPA® can be enhanced by administration with other preparation such as parasympatholytics and analgesics.
  • The administration of GLO SPA® with levodopa may result in reduced antiparkinson effect of the latter.
  • GLO SPA® is safe, which is non-toxic and non teratogenic, it should be administered to pregnant and breast feeding mothers only when clearly indicated and when potential benefits outweigh the potential risks.
  • GLO SPA® is generally well- tolerated, gastrointestinal disturbances, headache, vertigo and orthostatic hypotension may occur on rare occasions.

Over dosage:

  • In case of over dosage, symptoms include reduced gastric motility, hypotension, drowsiness, and cardiovascular disturbance.Treatment should be symptomatic.


  • 1- 2 tablets, 1- 3 times daily.
  • Blisters of 10 tablets, packs of two blisters.
  • Store in a dry place at a temperature below 25°C, protect from light.