Eromed 200
broad spectrum macrolide antibiotic with bactericidal
  • Erythromycin is a macrolide antibiotic with a broad bacteriostatic action against many Gram-positive and to a lesser extent some Gram-negative bacteria, as well as other organisms including Mycoplasmas, Spirochaetes, Chlamydias, Rickettsias Actinomycesand some Opportunistic Mycobacteria .
  • Orally administered Erythromycin Ethylsuccinate suspension is readily and reliably absorbed under both fasting and non fasting conditions.
  • The stearate salt is poorly soluble in water
  • Food may reduce the absorption of the stearate,  although this depends to some extent on the formulation so the optimal blood level are achieved when it’s taken on an empty stomach.  
  • The peak plasma concentrations generally occur between 1- 4 hours after administration, and  have been  reported to range between  about 0.3 - 0.5µg /ml after administration of 250mg  of Erythromycin base, and from 0.3 - 1.9 µg/ml after administration of 500mg .
  • The half life of  Erythromycin is usually reported to be roughly in the  range 1.5 - 2.5 hours .
  • Erythromycin diffuses readily into most body fluids. 
  • In the presence of normal hepatic function Erythromycin concentration is increased  in the liver and excreted in the bile. 
  • Erythromycin crosses the placental barrier and excreted in breast milk.  

Each Film Coated Tablet of  EROMED® 500 mg  contains: 

  • Erythromycin 500mg (as Erythromycin Stearate )

Each Film Coated Tablet of  EROMED® 250 mg  contains: 

  • Erythromycin 250mg (as Erythromycin Stearate )

Each 5 ml of EROMED® 200 mg  for oral suspension contains: 

  • Erythromycin 200mg (as Erythromycin Ethylsuccinate ) 

Each 5 ml of EROMED® 125 mg for oral suspension contains: 

  • Erythromycin 125mg (as Erythromycin Ethylsuccinate )

EROMED® is  used in the treatment of a wide variety of infections caused by susceptible organisms:

  • Its uses have included: bronchitis,  severe campylobacter enteritis, chancroid,  diphtheria,  legionnaire’s disease  and other Legionella infections,  neonatal conjunctivitis, pertussis, pneumonia, sinusitis and trench fever. 
  • Combined with Neomycin, for the prophylaxis of surgical infection in patients undergoing bowel surgery. 
  • EROMED®  is used as an alternative to penicillin in penicillin-allergic patients with various conditions. 
  • EROMED® is contraindicated in patients with known hypersensitivity to this antibiotic. 
  • EROMED® is contraindicated in patients taking Terfenadine, Astemizole or Cisapride.
  • Erythromycin used in patients who are receiving high doses of Theophylline may be associated with an increase in serum Theophylline levels and potentiate Theophylline toxicity. 
  • Concomitant administration of Erythromycin and Digoxin has been reported to result in elevated Digoxin serum levels. 
  • There have been reports of increased anticoagulant effects when Erythromycin  and Oral anticoagulants were used concomitantly. 
  • Serum concentrations of drugs metabolized by the Cytochrome P450 system should be monitored closely in patients concurrently receiving Erythromycin.
  •   Administer under medical supervision.  

The most frequent side effects are gastrointestinal disturbances and are dose-related they include:

  • nausea
  • vomiting
  • abdominal pain
  • diarrhea
  • anorexia .


The usual dose 1 to 2 g daily in 2 to 4 divided doses.

  • For severe infections this may be increased to up to 4 g daily in divided doses. 
  • A maximum of 1.5g daily has been suggested for patients with severe renal impairment. 

Children :

The usual dose about 30 to 50 mg/kg of body weight daily in divided doses although it may be doubled in severe infections.

  • A recommended dose for children aged 2-8 years is l g daily in divided doses. 
  • Infants and children up to 2years of age 500mg daily in divided doses. 
  • or as directed by the physician.
  • Caution should be exercised when EROMED® is administered to patients with impaired hepatic function. 
  • Prolonged or repeated use of  EROMED®  may result in an overgrowth of non susceptible bacteria or fungi. If superinfection occurs, EROMED® should be discontinued and appropriate therapy instituted. 
  • Abnormal liver function test results may occur. 

Film Coated Tablets 500mg &250 mg .

  • (Blisters  of 10 Tablets, Pack of 2 Blisters )  .

Oral suspension 200mg &125 mg .

  • (Bottles  of  100 ml after reconstitution) .

* Hospital packs of different sizes .

  • Store the drug  tightly closed in a dry place at a temperature below 25oC.
  • After reconstitution, store in a refrigerator and use within one week  .