Depacot 200
  • The active substance in DEPACOT® is sodium valproate which has anticonvulsant effect properties including various types of human epilpesy.

Each Gastro resistant tablet of DEPACOT® 200 contains:

  •  Sodium valproate        200 mg 

Each 5 ml of DEPACOT® Solution contains:

  •  Sodium valproate        250 mg 

DEPACOT® is used:

  • for treatment of various types of seizures of epilepsy.
  • in children to prevent fever related seizures.

DEPACOT® is contrainticated in:

  • Hypersensitivity to sodium valproate or to any other ingredients.
  • Disturbed function of the liver or pancrease.
  • Taking mefloquine & lamotrigine and St. John Wort plant.
  • DEPACOT® should not be taken with Mefloquine (medicine used to treat malaria),
  • St.johns wort (Plant-based medicine used to treat depression).
  • Salicylates should not be given with DEPACOT®.
  • The dosage of antidepressant, anticonvulsants and anticoagulant should be reduced when administration concomitantly with DEPACOT®.
  • you must tell your doctor if you are taking lamotrgine (another medicine used to treat epilepsy) or penems (antibiotics used to treat bacterial infection) or any other medicines.
  • Inform your doctor or pharmacist if you are taking or have recently taken any other medicines. 

¤ You must not take DEPACOT®:

  • if you are pregnant or of childbearing age unless otherwise indicated by your doctor.
  • if you are of chidbearing age, you must use a reliable means of contraception during treatment.
  • Taking DEPACOT® during pregnancy can cause fetal malformations, coagulation disorders in the newborn baby and developmental disorders or autism in the child.
  • Before stopping your contraception tell your doctor that you are planning to have a baby so that the doctor can possibly adjust your treatment and establish a special monitoring program for your pregnancy.
  • Also tell your doctor immediately if you discover that you are pregnant.
  • In all cases you must not stop your treatment by your own without the agreement of your doctor.
  • Breast-feeding is not recommended during treatment with DEPACOT®.

Like all medicines, DEPACOT® can cause side effects, although not every body gets them.

  • damage to the liver (hepatitis) or pancreas (pancreatitis), which may be serious and life-threatening and which may begin suddenly with fatigue, loss of appetite, exhaustion, drowsiness, nausea, vomiting, stomach pain.

Other possible side effects:

  • Birth defects and disturbances in cognitive and motor development 

Very common (affecting more than 1 in 10 people):

  • nausea, tremors, vomiting, stomach pain, diarrhea, weight gain, headache, drowsiness, convulsions, memory disorders, confusion, aggressiveness,agitation, disturbances in attention, hallucinations (seeing, hearing or smelling things that do not exist), extrapyramidal disorders (a set of symptoms such as tremors, stiffness in the limbs and difficulty walking) urinary incontinence (inability to retain urine), rapid and uncontrollable eye movements, hearing loss, gum diseases (gingival disorders), in particular an increase in gum volume (gingival hypertrophy), painful, swollen mouth, mouth ulcers and burning sensation in the mouth (stomatitis), hair loss, period disturbances (menstrual irregularity), bleeding,
  • decrease in platelet count (thrombocytopenia), decrease in red blood cell count (anemia),
  • decrease in the amount of sodium in the blood (hyponatremia, syndrome of inappropriate antidiuretic hormone secretion).

Uncommon (affecting up to 1 in 100 people):

  • vigilance disorders, which can lead to a temporary coma, which regresses afterthe dose is reduced or treatment is stopped.
  • difficulties in coordinating one's movements.
  • reversible parkinsonian syndrome.
  • numbness or tingling in the hands and feet.
  • abnormal hair texture, changes in hair color, abnormal hair growth,
  • excessive hairiness, especially in women, virilism, acne (hyperandrogenism),
  • drop in body temperature (hypothermia).
  • swelling of the extremities (edema).
  • amenorrhea (absence of periods).
  • increase in the number and severity of seizures, occurrence of seizures of different types.
  • breathing difficulty and pain due to inflammation of the protective membrane of the lung (pleural effusion), decrease in all blood cells: white blood cells, red blood cells and platelets (pancytopenia), decreased white blood cell count (leukopenia).
  • inflammation of the blood vessels.


  • If you take over dosage from DEPACOT® you should contact the doctor directly or go to the nearest hospital , Even if there are no signs of discomfort.

DEPACOT® treatment must be started and supervised by a doctorspecialised in the treatment of epilepsy, so you should take drug exactly as your doctor has told you.

  • Adults: The dose of DEPACOT® 200 tablets to be taken and controlled is determined individually by the physician and is generally divided into 2 or 3 doses per day, preferably with meals.
  • Children: The primary dose of DEPACOT® solution depend on body weight and seriousity of case and patient experience to medicine
  • DEPACOT® can in very rare cause liver damage (hepatitis) or pancreas damage (panceratitis) which can be serious and life-threatening.
  • your doctor will prescribe blood tests to regularly monitor your liver function, particularly during the first 6 months of treatment.

inform your doctor immediately if any of the following signs appear:

  • Sudden fatigue, loss of appetite, exhaustion, drowsiness, swelling of the legs,general malaise, repeated vomiting, nausea, stomach or bowel pain, yellow color of skin or eyes (jaundice), recurrence of epileptic seizures even though you are taking your treatment correctly.
  • Before taking DEPACOT® tell your doctor if you have kidney disease (renal insufficiency), systemic lupus erythematosus (rare disease)or hereditary enzyme deficiencies, particulaly an enzyme deficiency of urea cycle that can cause increased amounts of ammonia in the blood.
  • if you are scheduled to have surgery, you must inform the medical personnel that you are taking DEPACOT®.
  • Do not stop taking DEPACOT® without asking your doctor advice.
  • Treatment must be stopped gradually. If you stop taking DEPACOT® suddenly or before your doctor asks you to,- you will be exposed to an increased risk of seizures.

Effects on ability to drive and use machines:

  • DEPACOT® may impair your ability to drive or operate any tools or machinery, as it may make you feel sleepy. This is more likely at the beginning of treatment or after an increase in the dose. You should not drive or use machines until it is established that your ability to perform such activities is not affected.
  • DEPACOT® 200 mg tablets: Blister of 10 tablets, Pack of two blisters. 
  • DEPACOT® Solution: Bottle of 100 ml solution.  
  • Store at a temperature below 25°C, protected from light.